PIF1, PIF1 5'-to-3' DNA helicase

PIF1, PIF1 5'-to-3' DNA helicase

• This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]

• Gene Synonyms (ATP-dependent DNA helicase PIF1, DNA repair and recombination helicase PIF1, PIF1 5'-to-3' DNA helicase homolog, PIF1/RRM3 DNA helicase-like protein, petite integration frequency 1, C15orf20, PIF,)
• NCBI Gene ID: 80119
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H611
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PIF1 5'-to-3' DNA helicase interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.