TXNDC5, thioredoxin domain containing 5

TXNDC5, thioredoxin domain containing 5

• This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

• Gene Synonyms (thioredoxin domain-containing protein 5, ER protein 46, endoplasmic reticulum protein ERp46, endoplasmic reticulum resident protein 46, endothelial protein disulphide isomerase, epididymis secretory sperm binding protein, protein disulfide isomerase family A, member 15, thioredoxin domain containing 5 (endoplasmic reticulum), thioredoxin related protein, thioredoxin-like protein p46, ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364,)
• NCBI Gene ID: 81567
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024QZV0
  UNIPROT ID#>>Q8NBS9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thioredoxin domain containing 5 interacts with:

• alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  calreticulin 3
  flagellum associated containing coiled-coil domains 1
  histone deacetylase 10
  jumonji domain containing 8
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-5
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 4-12
  keratin associated protein 4-2
  LIM homeobox 4
  notch 2 N-terminal like A
  protein phosphatase 1 regulatory subunit 21
  protein tyrosine phosphatase non-receptor type 5
  RAB3A interacting protein
  ring finger protein 157
  tripartite motif containing 42

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.