APH1B, aph-1 homolog B, gamma-secretase subunit

APH1B, aph-1 homolog B, gamma-secretase subunit

• This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]

• Gene Synonyms (gamma-secretase subunit APH-1B, APH1B gamma secretase subunit, anterior pharynx defective 1 homolog B, aph-1beta, APH-1B, PRO1328, PSFL, TAAV688,)
• NCBI Gene ID: 83464
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WW43
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aph-1 homolog B, gamma-secretase subunit interacts with:

• FXYD6-FXYD2 readthrough
  trafficking regulator of GLUT4 (SLC2A4) 1
  V-set and transmembrane domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.