BCL2L12, BCL2 like 12

BCL2L12, BCL2 like 12

• This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

• Gene Synonyms (bcl-2-like protein 12, BCL2-like 12 (proline rich), Bcl-2 related proline-rich protein,)
• NCBI Gene ID: 83596
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HB09
  UNIPROT ID#>>I6LJZ8
  UNIPROT ID#>>I6LJZ6
  UNIPROT ID#>>I6LJZ9
  UNIPROT ID#>>I6LJZ7
  UNIPROT ID#>>I6LJZ5
  UNIPROT ID#>>A0A0X9JFN5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL2 like 12 interacts with:

• DDB1 and CUL4 associated factor 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.