OBSCN, obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

OBSCN, obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

• The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (obscurin, obscurin, myosin light chain kinase, obscurin-MLCK, ARHGEF30, UNC89,)
• NCBI Gene ID: 84033
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5VST9
  UNIPROT ID#>>A6NGQ3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF interacts with:

• ARP1 actin-related protein 1B, centractin beta
  BTB domain containing 8
  cell division cycle associated 5
  DDB1 and CUL4 associated factor 15
  ligand dependent nuclear receptor corepressor
  LY6/PLAUR domain containing 4
  metadherin
  potassium channel tetramerization domain containing 6
  SET domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.