KIRREL2, kirre like nephrin family adhesion molecule 2

KIRREL2, kirre like nephrin family adhesion molecule 2

• This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]

• Gene Synonyms (kin of IRRE-like protein 2, kin of IRRE like 2, kin of irregular chiasm-like protein 2, nephrin-like gene 1, nephrin-like protein 3, FILTRIN, NEPH3, NLG1,)
• NCBI Gene ID: 84063
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MQV3
  UNIPROT ID#>>A0A0A0MRC1
  UNIPROT ID#>>Q6UWL6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

kirre like nephrin family adhesion molecule 2 interacts with:

• phosphatidylinositol glycan anchor biosynthesis class S

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.