FAR1, fatty acyl-CoA reductase 1

FAR1, fatty acyl-CoA reductase 1

• The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]

• Gene Synonyms (fatty acyl-CoA reductase 1, male sterility domain-containing protein 2, short chain dehydrogenase/reductase family 10E, member 1, MLSTD2, PFCRD, SDR10E1,)
• NCBI Gene ID: 84188
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WVX9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

fatty acyl-CoA reductase 1 interacts with:

• egl-9 family hypoxia inducible factor 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.