RASAL1, RAS protein activator like 1

RASAL1, RAS protein activator like 1

• The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

• Gene Synonyms (rasGAP-activating-like protein 1, GAP1 like protein, ras GTPase-activating-like protein, RASAL,)
• NCBI Gene ID: 8437
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95294
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAS protein activator like 1 interacts with:

• GTPase activating protein and VPS9 domains 1
  nicotinate phosphoribosyltransferase
  Ras related GTP binding B

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