MAML2, mastermind like transcriptional coactivator 2

MAML2, mastermind like transcriptional coactivator 2

• The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]

• Gene Synonyms (mastermind-like protein 2, mam-2, mastermind-like 2, MAM-3, MAM2, MAM3, MLL-MAML2,)
• NCBI Gene ID: 84441
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IZL2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mastermind like transcriptional coactivator 2 interacts with:

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