GPT2, glutamic--pyruvic transaminase 2

GPT2, glutamic--pyruvic transaminase 2

• This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (alanine aminotransferase 2, glutamate pyruvate transaminase 2, glutamic pyruvate transaminase (alanine aminotransferase) 2, glutamic pyruvate transaminase 2, glutamic--alanine transaminase 2, ALT2, GPT 2, MRT49,)
• NCBI Gene ID: 84706
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6R2
  UNIPROT ID#>>Q8TD30
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutamic--pyruvic transaminase 2 interacts with:

• glycoprotein hormone subunit alpha 2
  thioesterase superfamily member 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.