TCAP, titin-cap

TCAP, titin-cap

• Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

• Gene Synonyms (telethonin, 19 kDa sarcomeric protein, limb girdle muscular dystrophy 2G (autosomal recessive), teneurin C-terminal associated peptide, titin cap protein, CMD1N, CMH25, LGMD2G, LGMDR7, T-cap, TELE, telethonin,)
• NCBI Gene ID: 8557
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15273
  UNIPROT ID#>>A2TDC0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

titin-cap interacts with:

• ankyrin repeat and SOCS box containing 6
  ankyrin repeat domain 2
  cell division cycle associated 4
  chromobox 5
  chromosome 19 open reading frame 54
  family with sequence similarity 153 member B
  IKAROS family zinc finger 3
  keratin associated protein 19-7
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
  LIM homeobox 4
  myozenin 1
  myozenin 2
  myozenin 3
  SIVA1 apoptosis inducing factor
  STIP1 homology and U-box containing protein 1
  suppressor APC domain containing 1
  tetratricopeptide repeat domain 19
  tripartite motif containing 55
  tripartite motif containing 63

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.