HSD17B6, hydroxysteroid 17-beta dehydrogenase 6

HSD17B6, hydroxysteroid 17-beta dehydrogenase 6

• The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]

• Gene Synonyms (17-beta-hydroxysteroid dehydrogenase type 6, 17-beta-HSD 6, 17-beta-hydroxysteroid dehydrogenase type 6 variant 1, 17-beta-hydroxysteroid dehydrogenase type 6 variant 2, 17-beta-hydroxysteroid dehydrogenase type 6 variant 3, 3(alpha->beta)-hydroxysteroid epimerase, 3(alpha->beta)-hydroxysteroid epimerasel, 3-alpha->beta-HSE, 3-hydroxysteroid epimerase, NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase, hydroxysteroid (17-beta) dehydrogenase 6 homolog, oxidative 3-alpha-hydroxysteroid-dehydrogenase, oxidoreductase, retinol dehydrogenase, short chain dehydrogenase/reductase family 9C member 6, HSE, RODH, SDR9C6,)
• NCBI Gene ID: 8630
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14756
  UNIPROT ID#>>A0A024RB43
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hydroxysteroid 17-beta dehydrogenase 6 interacts with:

• glucosamine-phosphate N-acetyltransferase 1
  keratinocyte proline rich protein
  phosphoribosyl transferase domain containing 1
  protein phosphatase 1 regulatory inhibitor subunit 14B
  sorting nexin 3
  TatD DNase domain containing 1
  testis expressed 101

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.