CHRD, chordin

CHRD, chordin

• This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]

• Gene Synonyms (chordin,)
• NCBI Gene ID: 8646
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E7ESX1
  UNIPROT ID#>>Q8N2W7
  UNIPROT ID#>>Q9H2X0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chordin interacts with:

• ADAMTS like 4
  cation channel sperm associated 1
  chordin like 2
  cysteine rich tail 1
  inhibitor of CDK, cyclin A1 interacting protein 1
  keratin associated protein 10-1
  keratin associated protein 10-3
  keratin associated protein 10-5
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 12-1
  keratin associated protein 12-2
  keratin associated protein 12-3
  keratin associated protein 1-3
  keratin associated protein 13-1
  keratin associated protein 19-2
  keratin associated protein 19-5
  keratin associated protein 22-1
  keratin associated protein 4-12
  keratin associated protein 4-2
  keratin associated protein 6-3
  keratin associated protein 9-2
  keratin associated protein 9-3
  late cornified envelope 1C
  late cornified envelope 1F
  late cornified envelope 5A
  lin-7 homolog A, crumbs cell polarity complex component
  NBPF member 19
  notch 2 N-terminal like A
  regulator of G protein signaling 17
  ring finger protein 123
  sprouty RTK signaling antagonist 1
  sprouty RTK signaling antagonist 2
  sprouty RTK signaling antagonist 3
  tripartite motif containing 42
  twisted gastrulation BMP signaling modulator 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.