PDE5A, phosphodiesterase 5A

PDE5A, phosphodiesterase 5A

• This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cGMP-specific 3',5'-cyclic phosphodiesterase, cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase, cGMP-specific phosphodiesterase PDE5A2, cGMP-specific phosphodiesterase type 5A, phosphodiesterase 5A, cGMP-specific, phosphodiesterase isozyme 5, CGB-PDE, CN5A, PDE5,)
• NCBI Gene ID: 8654
• Species: Homo sapiens (Human)
• UNIPROT ID#>>G5E9C5
  UNIPROT ID#>>O76074
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphodiesterase 5A interacts with:

• aryl hydrocarbon receptor interacting protein like 1
  centrosomal protein 43
  FKBP prolyl isomerase 15
  meiosis regulator for oocyte development
  POZ/BTB and AT hook containing zinc finger 1
  Rho related BTB domain containing 1
  SPG21 abhydrolase domain containing, maspardin
  WD repeat domain 24

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.