TNFSF12, TNF superfamily member 12

TNFSF12, TNF superfamily member 12

• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

• Gene Synonyms (tumor necrosis factor ligand superfamily member 12, APO3 ligand, APO3/DR3 ligand, TNF-related WEAK inducer of apoptosis, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand 4A, tumor necrosis factor superfamily member 12, APO3L, DR3LG, TNLG4A, TWEAK,)
• NCBI Gene ID: 8742
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43508
  UNIPROT ID#>>Q4ACW9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF superfamily member 12 interacts with:

• angiogenic factor with G-patch and FHA domains 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  TNF receptor superfamily member 12A
  TNF superfamily member 13b

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.