TNFRSF10C, TNF receptor superfamily member 10c

TNFRSF10C, TNF receptor superfamily member 10c

• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 10C, TNF-related apoptosis-inducing ligand receptor 3, antagonist decoy receptor for TRAIL/Apo-2L, cytotoxic TRAIL receptor-3, decoy TRAIL receptor without death domain, decoy receptor 1, lymphocyte inhibitor of TRAIL, tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID,)
• NCBI Gene ID: 8794
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14798
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 10c interacts with:

• ADP ribosylation factor like GTPase 13B
  ankyrin repeat, SAM and basic leucine zipper domain containing 1
  cAMP responsive element binding protein 3 like 1
  coenzyme Q9
  C-X-C motif chemokine ligand 14
  DnaJ heat shock protein family (Hsp40) member C1
  ERGIC and golgi 3
  family with sequence similarity 209 member A
  G protein-coupled receptor 152
  G protein-coupled receptor 37 like 1
  leucine rich repeat and sterile alpha motif containing 1
  mitochondrial ribosomal protein S18B
  PDZK1 interacting protein 1
  refilin B
  solute carrier family 27 member 6
  synapse associated protein 1
  transmembrane protein 45B
  transmembrane protein 80
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.