CCN6, cellular communication network factor 6

CCN6, cellular communication network factor 6

• This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cellular communication network factor 6, CCN family member 6, WNT1 inducible signaling pathway protein 3, epididymis secretory sperm binding protein, LIBC, PPAC, PPD, WISP-3, WISP3,)
• NCBI Gene ID: 8838
• Species: Homo sapiens (Human)
• UNIPROT ID#>>I6L968
  UNIPROT ID#>>O95389
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cellular communication network factor 6 interacts with:

• cysteine rich with EGF like domains 2
  DEAD-box helicase 47

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