CCN5, cellular communication network factor 5

CCN5, cellular communication network factor 5

• This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CCN family member 5, WNT1 inducible signaling pathway protein 2, connective tissue growth factor-like protein, connective tissue growth factor-related protein 58, CT58, CTGF-L, WISP2,)
• NCBI Gene ID: 8839
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O76076
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cellular communication network factor 5 interacts with:

• archaelysin family metallopeptidase 2
  cytosolic thiouridylase subunit 2
  histone deacetylase 3
  PITH domain containing 1
  tripartite motif containing 68

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.