PER2, period circadian regulator 2

PER2, period circadian regulator 2

• This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]

• Gene Synonyms (period circadian protein homolog 2, circadian clock protein PERIOD 2, hPER2, period 2, period circadian clock 2, period circadian protein 2, period homolog 2, FASPS, FASPS1,)
• NCBI Gene ID: 8864
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15055
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

period circadian regulator 2 interacts with:

• basic helix-loop-helix family member e41
  beta-transducin repeat containing E3 ubiquitin protein ligase
  casein kinase 1, epsilon
  clock circadian regulator
  F-box and WD repeat domain containing 11
  leukocyte receptor cluster member 8
  protein phosphatase 1 catalytic subunit alpha
  timeless circadian regulator
  TPTEP2-CSNK1E readthrough
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.