MVB12B, multivesicular body subunit 12B

MVB12B, multivesicular body subunit 12B

• The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

• Gene Synonyms (multivesicular body subunit 12B, ESCRT-I complex subunit MVB12B, family with sequence similarity 125, member B, C9orf28, FAM125B,)
• NCBI Gene ID: 89853
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R8B8
  UNIPROT ID#>>Q9H7P6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

multivesicular body subunit 12B interacts with:

• methyltransferase like 15
  multivesicular body subunit 12A
  solute carrier family 25 member 41
  VPS37A subunit of ESCRT-I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.