PAPSS1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1

PAPSS1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1

• Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

• Gene Synonyms (bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, 3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1, PAPS synthase 1, PAPSS 1, SK 1, adenylyl-sulfate kinase, sulfate adenylyltransferase, sulfurylase kinase 1, ATPSK1, PAPSS, SK1,)
• NCBI Gene ID: 9061
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43252
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

3'-phosphoadenosine 5'-phosphosulfate synthase 1 interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  coiled-coil domain containing 116
  ERBB receptor feedback inhibitor 1
  exportin for tRNA
  FA complementation group I
  NSFL1 cofactor
  odontogenesis associated phosphoprotein
  protein phosphatase 1 regulatory subunit 16A
  protein phosphatase 2, regulatory subunit A, alpha
  ras homolog family member A
  ribonuclease H2 subunit A
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  TatD DNase domain containing 1
  TNFAIP3 interacting protein 2
  transmembrane protein 132A
  tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
  tubulin beta 3 class III
  unc-119 lipid binding chaperone
  WD repeat and coiled coil containing
  YY1 associated factor 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.