KCNQ4, potassium voltage-gated channel subfamily Q member 4

KCNQ4, potassium voltage-gated channel subfamily Q member 4

• The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (potassium voltage-gated channel subfamily KQT member 4, potassium channel KQT-like 4, potassium channel subunit alpha KvLQT4, potassium channel, voltage gated KQT-like subfamily Q, member 4, potassium voltage-gated channel, KQT-like subfamily, member 4, DFNA2, DFNA2A, KV7.4,)
• NCBI Gene ID: 9132
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P56696
  UNIPROT ID#>>B3KQH8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

potassium voltage-gated channel subfamily Q member 4 interacts with:

• 5',3'-nucleotidase, mitochondrial
  calcium/calmodulin dependent protein kinase ID
  cytochrome P450 family 4 subfamily F member 12
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.