LRRFIP2, LRR binding FLII interacting protein 2

LRRFIP2, LRR binding FLII interacting protein 2

• The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

• Gene Synonyms (leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2, leucine rich repeat (in FLII) interacting protein 2, HUFI-2,)
• NCBI Gene ID: 9209
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y608
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

LRR binding FLII interacting protein 2 interacts with:

• actin, beta
  ATP synthase mitochondrial F1 complex assembly factor 2
  autophagy related 16 like 1
  coronin, actin binding protein 1C
  developmental pluripotency-associated 3
  dynactin 3
  flotillin 1
  flotillin 2
  golgi reassembly stacking protein 1
  HAUS augmin-like complex, subunit 4
  histone deacetylase 4
  integrin alpha 5 (fibronectin receptor alpha)
  LIM domain and actin binding 1
  myosin IC
  myosin VC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  N(alpha)-acetyltransferase 15, NatA auxiliary subunit
  peptidylprolyl isomerase E
  poly(A) specific ribonuclease subunit PAN2
  protein phosphatase 1 catalytic subunit beta
  ring finger protein 123
  ring finger protein 138
  SAMM50 sorting and assembly machinery component
  synaptopodin
  tripartite motif containing 14
  tropomodulin 3
  tropomodulin 3
  tropomodulin 4
  ubiquitin D
  UFM1 specific ligase 1
  USO1 vesicle docking factor
  vacuole membrane protein 1
  WW domain binding protein 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.