TIMM50, translocase of inner mitochondrial membrane 50

TIMM50, translocase of inner mitochondrial membrane 50

• This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016]

• Gene Synonyms (mitochondrial import inner membrane translocase subunit TIM50, Tim50-like protein, homolog of yeast Tim50, MGCA9, TIM50, TIM50L,)
• NCBI Gene ID: 92609
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R0M6
  UNIPROT ID#>>Q3ZCQ8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

translocase of inner mitochondrial membrane 50 interacts with:

• BPI fold containing family B member 1
  CDGSH iron sulfur domain 3
  coiled-coil-helix-coiled-coil-helix domain containing 10
  egl-9 family hypoxia inducible factor 3
  mucin 5B, oligomeric mucus/gel-forming
  NADH:ubiquinone oxidoreductase complex assembly factor 8
  protein tyrosine phosphatase mitochondrial 1
  sideroflexin 1
  translocase of inner mitochondrial membrane 23 homolog B
  tubulin alpha 3e
  tubulin, beta 4B class IVB
  tubulin, gamma 1
  zinc finger protein 100
  zinc finger protein 724
  zinc finger protein 746
  zinc finger protein 852

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.