DPH7, diphthamide biosynthesis 7

DPH7, diphthamide biosynthesis 7

• Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]

• Gene Synonyms (diphthine methyltransferase, WD repeat-containing protein 85, C9orf112, RRT2, WDR85,)
• NCBI Gene ID: 92715
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BTV6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

diphthamide biosynthesis 7 interacts with:

• DENN/MADD domain containing 6A
  inhibitor of CDK, cyclin A1 interacting protein 1
  neuropeptide B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.