MUC16, mucin 16, cell surface associated

MUC16, mucin 16, cell surface associated

• This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

• Gene Synonyms (CA125, mucin-16, CA125 ovarian cancer antigen, mucin-16 long isoform, mucin-16 short isoform, ovarian cancer-related tumor marker CA125, ovarian carcinoma antigen CA125,)
• NCBI Gene ID: 94025
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KY81
  UNIPROT ID#>>Q8WXI7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mucin 16, cell surface associated interacts with:

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