ABCG2, ATP binding cassette subfamily G member 2 (Junior blood group)

ABCG2, ATP binding cassette subfamily G member 2 (Junior blood group)

• The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

• Gene Synonyms (broad substrate specificity ATP-binding cassette transporter ABCG2, ABC transporter, ATP-binding cassette transporter G2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), breast cancer resistance protein, mitoxantrone resistance-associated protein, multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2, placenta specific MDR protein, placenta-specific ATP-binding cassette transporter, urate exporter, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1,)
• NCBI Gene ID: 9429
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RDD4
  UNIPROT ID#>>Q9UNQ0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATP binding cassette subfamily G member 2 (Junior blood group) interacts with:

• actin, beta
  charged multivesicular body protein 4B
  flotillin 1
  golgi transport 1B
  hepatitis A virus cellular receptor 1
  myosin VC
  myosin, heavy polypeptide 10, non-muscle
  PHD finger protein 12
  protein tyrosine phosphatase, non-receptor type 23
  RAB5C, member RAS oncogene family
  synaptopodin
  transmembrane p24 trafficking protein 2
  tripartite motif-containing 69
  tropomyosin 1, alpha
  UFM1 specific ligase 1
  vacuolar protein sorting 4B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.