Cell and Gene Therapy Solutions
Recent successes of cell and gene therapies have brought hope for treating previously untreatable diseases. However, many challenges still need to be addressed to enhance the development and broaden the availability of these therapies. To help overcome some of these challenges, we have developed a comprehensive suite of solutions designed to support you throughout the various stages of your cell and gene therapy development workflow.
What is Cell and Gene Therapy?
Cell therapy is a treatment method where cells are introduced into a patient's body to enhance immune responses or to repair or replace damaged tissue cells. Examples of this include CAR-T cell therapy and TCR-T cell therapy, where T cells are modified to specifically target cancer cells. In CAR-T cell therapy, T cells from a patient (autologous therapy) or a donor (allogeneic therapy) are modified to express a chimeric antigen receptor (CAR). This modification enables the T cells to recognize and attack specific cancer cell antigens. Once reintroduced into the patient's body, these engineered T cells can effectively detect, target, and destroy cancer cells. Despite existing challenges, the success of several CAR-T cell therapies highlights their potential as innovative treatments for disease.
Gene therapy is the use of genetic material to treat and prevent diseases by either modifying or introducing genes into a patient's cells. Advanced techniques like CRISPR-Cas9 are used for precise gene editing, allowing for specific modifications within the genome. This approach targets genetic disorders at their source, involving the delivery of genetic materials directly into the body to modify defective genes, silence disease-causing genes, or introduce new genes to combat conditions like cancer. Common methods include the use of viral vectors, such as adeno-associated virus (AAV) and lentivirus. Several AAV-based gene therapies have demonstrated success in treating various genetic disorders, highlighting the effectiveness and potential of this innovative treatment method.
Solutions for Cell and Gene Therapy
Want to accelerate your cell and gene therapy development workflow? Our innovative solutions were specifically developed using our core bioluminescence technology and/or a wide range of genomics tools. The benefits of our cell and gene therapy solutions include:
- Designed to have simple workflows
- Validated to ensure high consistency and quality
- Customizable to fit your specific needs
- Many of our products meet ICH guidelines
Explore the Cell, Gene or RNA Therapy pages below to learn more about specific solutions.
Cell Therapy
Gene Therapy
RNA Therapy
Featured Resources
![alterations-workingwith-rna-3](https://scv10mr-cdnpre-p-cus-00.azureedge.net/-/media/images/applications/molecular-oncology/alterations-in-gene-expressions/alterations-workingwith-rna-3.jpg?rev=0d3f30c0f6ce4e3f9aeea6417a5ffc7f&sc_lang=en)
Automated Nucleic Acid Extraction for Cell and Gene Therapy
Learn how to automate DNA and RNA extraction from a variety of cells and tissues using Maxwell® Instruments.![nanobit-introduction-video](https://scv10mr-cdnpre-p-cus-00.azureedge.net/-/media/images/applications/small-molecule-drug-discovery/kinase-biology/nanobit-introduction-video.jpg?rev=273b083ef5fc4fc08b8fc29de7d9fd7f&sc_lang=en)
Video: Target Cell Killing Bioassays
Learn about a solution for measuring CAR-T cell potency in this video interview with Promega scientist Dr. Julia Gilden.![lumit-resource-article](https://scv10mr-cdnpre-p-cus-00.azureedge.net/-/media/images/applications/small-molecule-drug-discovery/lumit-immunoassays/lumit-resource-article.jpg?rev=c865c24e33554101a15809ba44270064&sc_lang=en)
Blog: Silencing the Immunogenicity of AAV Vectors
Learn how researchers modified an AAV vector to avoid immune responses while maintaining vector function.Conferences and Events
2nd mRNA Process Development and Manufacturing Summit, April 2024, Frankfurt, Germany
ASGCT 27th Annual Meeting, May 2024, Baltimore, MD
Cell and Gene Therapy Products (CGTP) Symposium, June 2024, Rockville, MD
3rd Annual Gene Therapy Development Congress, June 2024, London, UK
4th Annual mRNA-Based Therapeutics Summit, July 2024, Boston, MA
2nd Annual mRNA Process Development & Manufacturing Summit, September 2024, Boston, MA
31st ESGCT Annual Congress, October 2024, Rome, Italy
6th Annual Gene Therapy Analytical Development Summit, November 2024