The Heater Shaker Magnet Instrument (HSM 2.0) is designed to perform all of the functions necessary for the processing of magnetic resin-based purification chemistries in large-volume formats. With its ability to heat, shake and apply a magnetic field, the HSM 2.0 Instrument provides all-in-one processing capabilities for a variety of large-volume purification chemistries in either a manual or automated format. The instrument uses standard 50ml conical tubes, magnets and reagent-based paramagnetic particles (PMPs). The PMPs provide a mobile solid phase that optimizes capture, washing and elution of biological target molecules.
Initially designed to run the ReliaPrep™ Large Volume HT gDNA Isolation System (Cat.# A2751), the HSM 2.0 Instrument is supplied with software containing preprogrammed isolation methods for processing up to 32 samples of human whole blood in approximately 2–3.5 hours, depending on sample volume and number. Samples are processed in a semi-automated method with the user dispensing and aspirating reagents from the samples as directed by the software on a computer screen. The programmed methods control the heating, shaking, magnetization and timing of the steps required for the semi-automated purification. For fully automated purification, the HSM 2.0 Instrument can be integrated with a robotic liquid-handling workstation, which can process 32 samples in less than 4.5 hours.