ADCC Reporter Bioassay, Complete Kit (Raji)
Instructions for Use of Product(s)
G7016, G7015, GA1155
Literature # TM387
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a mechanism of action of antibodies through which virus-infected or other diseased cells are targeted for destruction by components of the cell-mediated immune system, such as natural killer cells. The ADCC Reporter Bioassay is a bioluminescent reporter assay for quantifying biological activity on pathway activation by therapeutic antibody drugs in an ADCC mechanism of action (MOA) assay. The ADCC Reporter Bioassay, Complete Kit (Raji) contains all of the components and reagents necessary to perform an anti-CD20-based ADCC Reporter Bioassay. The kit provides Control Ab, Anti-CD20, and is an ideal way for a new user to become acquainted with the bioassay.
Summary of Changes
The following changes were made to the 11/23 revision of this document:
1. Updated the concentration of Control Ab, Anti-CD20, in Sections 2 and 4.B.
2. Updated Section 8.
3. Changed font and cover image.
4. Updated patent statements.
5. Made minor text updates.
Revised 11/23.
