- Gene Overview
- Interaction Network
- Sequence Verification
TCIRG1, T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
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This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
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Gene Synonyms (ATP6N1C, ATP6V0A3, Atp6i, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1, a3, V-type proton ATPase 116 kDa subunit a3, V-type proton ATPase 116 kDa subunit a, ATPase, H+ transporting, 116kD, T-cell immune response cDNA 7, T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a, T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, V-ATPase 116 kDa subunit a3, V-ATPase 116-kDa, osteoclastic proton pump 116 kDa subunit, specific 116-kDa vacuolar proton pump subunit, vacuolar proton translocating ATPase 116 kDa subunit A,)
- NCBI Gene ID:
10312
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q13488
UNIPROT ID#>>A0A024R5E5
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Gene products are often involved in multiple pathways and networks within a living
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T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 interacts with:
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