ERLIN1, ER lipid raft associated 1

ERLIN1, ER lipid raft associated 1

• The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016]

• Gene Synonyms (C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62, erlin-1, Band_7 23-211 Keo4 (Interim) similar to C.elegans protein C42C1.9, SPFH domain family, member 1, SPFH domain-containing protein 1, endoplasmic reticulum lipid raft-associated protein 1, stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1,)
• NCBI Gene ID: 10613
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D3DR65
  UNIPROT ID#>>O75477
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ER lipid raft associated 1 interacts with:

• ankyrin repeat and SOCS box containing 11
  anterior gradient 3, protein disulphide isomerase family member
  bone morphogenetic protein receptor, type 1A
  calmodulin-like 3
  CD2-associated protein
  charged multivesicular body protein 2A
  charged multivesicular body protein 4B
  chromosome 6 open reading frame 120
  coiled-coil-helix-coiled-coil-helix domain containing 6
  complement component 1, q subcomponent binding protein
  cytoskeleton associated protein 5
  DISC1 scaffold protein
  ER degradation enhancing alpha-mannosidase like protein 3
  ER lipid raft associated 2
  Fas associated factor family member 2
  fatty acid 2-hydroxylase
  F-box and WD repeat domain containing 8
  F-box protein 6
  golgi transport 1B
  kinectin 1
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  myelin expression factor 2
  NADH:ubiquinone oxidoreductase subunit A12
  ninein
  pleckstrin homology domain containing A4
  RAB5C, member RAS oncogene family
  RALY heterogeneous nuclear ribonucleoprotein
  regulator of microtubule dynamics 3
  ribosome binding factor A
  ring finger protein 139
  ring finger protein 170
  RPGRIP1 like
  SEC22 homolog A, vesicle trafficking protein
  solute carrier family 15 member 3
  spastin
  SUZ12 polycomb repressive complex 2 subunit
  synoviolin 1
  transmembrane and ubiquitin like domain containing 2
  transmembrane p24 trafficking protein 2
  transmembrane protein 199
  transmembrane protein 41B
  transmembrane protein 63B
  tumor susceptibility gene 101
  UBA domain containing 2
  UFM1 specific ligase 1
  unc-93 homolog B1, TLR signaling regulator
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.