HSPH1, heat shock protein family H (Hsp110) member 1

HSPH1, heat shock protein family H (Hsp110) member 1

• This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

• Gene Synonyms (HSP105, HSP105A, HSP105B, NY-CO-25, heat shock protein 105 kDa, antigen NY-CO-25, heat shock 105kDa/110kDa protein 1,)
• NCBI Gene ID: 10808
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DY72
  UNIPROT ID#>>A0A0A0MSM0
  UNIPROT ID#>>Q92598
  UNIPROT ID#>>A0A024RDS1
  UNIPROT ID#>>A0A024RDQ0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock protein family H (Hsp110) member 1 interacts with:

• AAR2 splicing factor
  adducin 1 (alpha)
  B cell linker
  BICD cargo adaptor 2
  COMM domain containing 3
  cyclic GMP-AMP synthase
  DnaJ heat shock protein family (Hsp40) member A4
  DnaJ heat shock protein family (Hsp40) member B4
  DnaJ heat shock protein family (Hsp40) member C17
  dynactin subunit 4
  dynein light chain roadblock-type 1
  egl-9 family hypoxia inducible factor 3
  ER degradation enhancing alpha-mannosidase like protein 3
  exportin 7
  Fas associated factor 1
  F-box protein 6
  glutamate rich WD repeat containing 1
  GrpE like 1, mitochondrial
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  heparanase
  hook microtubule tethering protein 1
  kinase suppressor of ras 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  methylphosphate capping enzyme
  methyltransferase like 21A
  methyltransferase like 3
  mitochondrial carrier 2
  neutrophil cytosolic factor 1
  parvin alpha
  PH domain and leucine rich repeat protein phosphatase 2
  phosphoglycerate kinase 1
  PIH1 domain containing 1
  platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
  pleckstrin homology domain containing A4
  protein tyrosine phosphatase non-receptor type 23
  pseudouridine synthase 7
  required for meiotic nuclear division 5 homolog A
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  serine/threonine kinase 39
  stress induced phosphoprotein 1
  TAR DNA binding protein
  TNFAIP3 interacting protein 2
  transgelin 3
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin-like modifier activating enzyme 1
  vir like m6A methyltransferase associated
  WD repeat domain 76
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger and BTB domain containing 7B
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.