B4GALT7, beta-1,4-galactosyltransferase 7

B4GALT7, beta-1,4-galactosyltransferase 7

• This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]

• Gene Synonyms (beta-1,4-galactosyltransferase 7, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7, UDP-galactose:beta-xylose beta-1,4-galactosyltransferase, beta-1,4-GalTase 7, beta-1,4-galactosyltransferase VII, beta4Gal-T7, beta4GalT-VII, galactosyltransferase I, proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I, xylosylprotein 4-beta-galactosyltransferase, xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7, xylosylprotein beta-1,4-galactosyltransferase, EDSP1, EDSSLA, EDSSPD1, XGALT1, XGPT, XGPT1,)
• NCBI Gene ID: 11285
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBV7
  UNIPROT ID#>>B3KMT1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-1,4-galactosyltransferase 7 interacts with:

• BTB domain containing 8
  centrosomal protein 152
  charged multivesicular body protein 3
  cysteine rich tail 1
  glycoprotein integral membrane 1
  intermediate filament family orphan 1
  keratin associated protein 10-3
  keratin associated protein 10-7
  metallophosphoesterase 1
  transmembrane p24 trafficking protein 2
  transmembrane protein 14B
  transmembrane protein 192
  twinkle mtDNA helicase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.