EMX2, empty spiracles homeobox 2

EMX2, empty spiracles homeobox 2

• This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]

• Gene Synonyms (homeobox protein EMX2, empty spiracles homolog 2, empty spiracles-like protein 2,)
• NCBI Gene ID: 2018
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q04743
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

empty spiracles homeobox 2 interacts with:

• general transcription factor IIA subunit 1 like
  Meis homeobox 1
  OTU deubiquitinase 6A
  TLE family member 2, transcriptional corepressor

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