IL13, interleukin 13

IL13, interleukin 13

• This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

• Gene Synonyms (interleukin-13, IL-13, P600,)
• NCBI Gene ID: 3596
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35225
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 13 interacts with:

• interleukin 13 receptor subunit alpha 1
  interleukin 13 receptor subunit alpha 2
  phosphoinositide-3-kinase regulatory subunit 1
  vascular cell adhesion molecule 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.