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IL15RA, interleukin 15 receptor subunit alpha

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IL15RA, interleukin 15 receptor subunit alpha

  • This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

  • Gene Synonyms (interleukin-15 receptor subunit alpha, interleukin 15 receptor alpha isoform EM2, interleukin 15 receptor alpha isoform IC2, interleukin 15 receptor alpha isoform IC3, interleukin 15 receptor alpha isoform IC4, interleukin 15 receptor alpha isoform IC5, interleukin 15 receptor alpha isoform IC6, interleukin 15 receptor alpha isoform IC7, interleukin 15 receptor alpha isoform IC8, interleukin 15 receptor, alpha, CD215,)
  • NCBI Gene ID: 3601
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>A0A0A0MS77
    UNIPROT ID#>>G8CVM3
    UNIPROT ID#>>Q13261
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 15 receptor subunit alpha interacts with:

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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