MEP1B, meprin A subunit beta

MEP1B, meprin A subunit beta

• Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]

• Gene Synonyms (meprin A subunit beta, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta, N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit, PABA peptide hydrolase, PPH beta, endopeptidase-2, meprin A, beta, meprin B,)
• NCBI Gene ID: 4225
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16820
  UNIPROT ID#>>J3QKX5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

meprin A subunit beta interacts with:

• meprin A subunit beta
  neuropeptide Y
  OS9 endoplasmic reticulum lectin
  peptide YY
  protein kinase C delta
  protein kinase cAMP-activated catalytic subunit alpha
  secretin

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