WNT4, Wnt family member 4

WNT4, Wnt family member 4

• The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein Wnt-4, wingless-type MMTV integration site family, member 4, SERKAL, WNT-4,)
• NCBI Gene ID: 54361
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P56705
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Wnt family member 4 interacts with:

• BORA aurora kinase A activator
  COBW domain containing 3
  cysteine rich with EGF like domains 2
  Fraser extracellular matrix complex subunit 1
  integrator complex subunit 14
  lipase maturation factor 1
  porcupine O-acyltransferase
  transmembrane protein 80
  Wnt ligand secretion mediator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.