FANCL, FA complementation group L

FANCL, FA complementation group L

• This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2018]

• Gene Synonyms (E3 ubiquitin-protein ligase FANCL, Fanconi anemia complementation group L, PHD finger protein 9, RING-type E3 ubiquitin transferase FANCL, fanconi anemia group L protein, fanconi anemia-associated polypeptide of 43 kDa, FAAP43, PHF9, POG,)
• NCBI Gene ID: 55120
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NW38
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FA complementation group L interacts with:

• adenine nucleotide translocase lysine methyltransferase
  ATR interacting protein
  centromere protein S
  centromere protein X
  chromosome 19 open reading frame 54
  CTD small phosphatase 1
  dedicator of cytokinesis 8
  eukaryotic translation initiation factor 4E nuclear import factor 1
  FA complementation group I
  FA complementation group L
  FA complementation group M
  FA core complex associated protein 100
  FA core complex associated protein 20
  FA core complex associated protein 24
  gametogenetin
  haloacid dehalogenase like hydrolase domain containing 3
  interactor of HORMAD1 1
  keratin associated protein 11-1
  keratin associated protein 13-2
  keratin associated protein 19-6
  leucine zipper tumor suppressor 2
  methyltransferase like 15
  MORN repeat containing 3
  RIMS binding protein 3
  RNA binding motif protein 45
  sodium channel modifier 1
  SSX family member 2 interacting protein
  ubiquitin conjugating enzyme E2 W
  UFM1 specific peptidase 1 (inactive)
  V-set and immunoglobulin domain containing 1
  yippee like 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.