LRRC8A, leucine rich repeat containing 8 VRAC subunit A

LRRC8A, leucine rich repeat containing 8 VRAC subunit A

• This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AGM5, LRRC8, SWELL1, volume-regulated anion channel subunit LRRC8A, leucine rich repeat containing 8 family member A, leucine-rich repeat-containing protein 8A, swelling protein 1,)
• NCBI Gene ID: 56262
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IWT6
  UNIPROT ID#>>A0A024R892
  UNIPROT ID#>>A8K1C7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine rich repeat containing 8 VRAC subunit A interacts with:

• 5-hydroxytryptamine receptor 3C
  delta like non-canonical Notch ligand 2
  inositol-pentakisphosphate 2-kinase
  popeye domain containing 2
  ribosomal protein L35
  transmembrane protein 30B
  zinc activated ion channel

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.