OVOL2, ovo like zinc finger 2

OVOL2, ovo like zinc finger 2

• This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

• Gene Synonyms (transcription factor Ovo-like 2, corneal endothelial dystrophy 1 (autosomal dominant), zinc finger protein 339, CHED, CHED1, CHED2, EUROIMAGE566589, PPCD1, ZNF339,)
• NCBI Gene ID: 58495
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BRP0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ovo like zinc finger 2 interacts with:

• zinc finger protein 526

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.