PGA4, pepsinogen A4

PGA4, pepsinogen A4

• This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]

• Gene Synonyms (pepsin A-4, pepsinogen 4, group I (pepsinogen A), pepsinogen-4, pregnancy-associated glycoprotein,)
• NCBI Gene ID: 643847
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P0DJD7
  UNIPROT ID#>>B7Z719
  UNIPROT ID#>>A0A1S5UZ02
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pepsinogen A4 interacts with:

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