HNF1A, HNF1 homeobox A

HNF1A, HNF1 homeobox A

• The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• Gene Synonyms (hepatocyte nuclear factor 1-alpha, HNF-1-alpha, albumin proximal factor, hepatic nuclear factor 1, interferon production regulator factor, liver-specific transcription factor LF-B1, transcription factor 1, hepatic, truncated hepatocyte nuclear factor 1 alpha, HNF-1A, HNF1, HNF4A, IDDM20, LFB1, MODY3, TCF-1, TCF1,)
• NCBI Gene ID: 6927
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P20823
  UNIPROT ID#>>E0YMI7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HNF1 homeobox A interacts with:

• chromobox 3
  elongator acetyltransferase complex subunit 3
  GATA binding protein 5
  H2A clustered histone 21
  H4 histone 16
  HNF1 homeobox A
  HNF1 homeobox B
  lysine acetyltransferase 2B
  nuclear receptor coactivator 1
  nuclear receptor coactivator 3
  pterin-4 alpha-carbinolamine dehydratase 2
  rhophilin Rho GTPase binding protein 2
  ring finger protein 14
  sirtuin 1
  sorting nexin 14
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  TLE family member 1, transcriptional corepressor
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  valosin containing protein
  vimentin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.