KLF11, Kruppel like factor 11

KLF11, Kruppel like factor 11

• The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

• Gene Synonyms (Krueppel-like factor 11, TGFB-inducible early growth response protein 2, TIEG-2, transforming growth factor-beta-inducible early growth response protein 2, FKLF, FKLF1, MODY7, TIEG2, Tieg3,)
• NCBI Gene ID: 8462
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7ZAX4
  UNIPROT ID#>>Q53QU8
  UNIPROT ID#>>O14901
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Kruppel like factor 11 interacts with:

• amyloid beta precursor protein binding protein 2
  aph-1 homolog A, gamma-secretase subunit
  chromobox 1
  chromobox 3
  chromobox 5
  mitogen-activated protein kinase 1
  SIN3 transcription regulator family member A
  thioredoxin domain containing 9
  translocase of inner mitochondrial membrane 13

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.