BCAR1, BCAR1 scaffold protein, Cas family member

BCAR1, BCAR1 scaffold protein, Cas family member

• The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]

• Gene Synonyms (breast cancer anti-estrogen resistance protein 1, BCAR1, Cas family scaffold protein, BCAR1, Cas family scaffolding protein, Cas scaffolding protein family member 1, Crk-associated substrate p130Cas, CAS, CAS1, CASS1, CRKAS, P130Cas,)
• NCBI Gene ID: 9564
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P56945
  UNIPROT ID#>>B3KWE2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCAR1 scaffold protein, Cas family member interacts with:

• ajuba LIM protein
  ankyrin repeat and sterile alpha motif domain containing 1A
  armadillo repeat containing X-linked 3
  breast cancer anti-estrogen resistance 3
  CD2 associated protein
  docking protein 7
  dynactin 3
  embryonal Fyn-associated substrate
  epsin 1
  family with sequence similarity 102 member A
  family with sequence similarity 90 member A1
  FXYD domain containing ion transport regulator 6
  GLIS family zinc finger 2
  guanosine monophosphate reductase 2
  hypoxia up-regulated 1
  kinesin family member 13A
  mannose-6-phosphate receptor, cation dependent
  PML-RARA regulated adaptor molecule 1
  proteasome 26S subunit, non-ATPase 14
  protein kinase N3
  protein kinase N3
  protein phosphatase 1 regulatory subunit 15A
  Rho GTPase activating protein 32
  SH2 domain containing 3A
  SH2 domain containing 3C
  SH3 domain containing kinase binding protein 1
  SRC kinase signaling inhibitor 1
  tensin 3
  tet methylcytosine dioxygenase 2
  TNFAIP3 interacting protein 2
  tRNA splicing endonuclease subunit 34
  tubulin, alpha 1A
  tyrosine kinase non receptor 2
  ubiquitin like with PHD and ring finger domains 2
  VPS11 core subunit of CORVET and HOPS complexes

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.