RAPGEF2, Rap guanine nucleotide exchange factor 2

RAPGEF2, Rap guanine nucleotide exchange factor 2

• Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (rap guanine nucleotide exchange factor 2, PDZ domain containing guanine nucleotide exchange factor (GEF) 1, PDZ domain-containing guanine nucleotide exchange factor 1, RA(Ras/Rap1A-associating)-GEF, Rap guanine nucleotide exchange factor (GEF) 2, cyclic nucleotide ras GEF, neural RAP guanine nucleotide exchange protein, ras/Rap1-associating GEF-1, CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, RAGEF, Rap-GEP, nRap GEP,)
• NCBI Gene ID: 9693
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y4G8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rap guanine nucleotide exchange factor 2 interacts with:

• anoctamin 3
  ATP synthase membrane subunit DAPIT
  B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  cortactin binding protein 2
  ERI1 exoribonuclease family member 3
  erythrocyte membrane protein band 4.1 like 5
  F-box and WD repeat domain containing 11
  H4 clustered histone 15
  hemicentin 1
  leucine aminopeptidase 3
  leucine rich repeat protein 1
  membrane associated guanylate kinase, WW and PDZ domain containing 2
  membrane associated guanylate kinase, WW and PDZ domain containing 3
  mesoderm development LRP chaperone
  MOB family member 4, phocein
  moesin
  potassium channel tetramerization domain containing 17
  potassium channel tetramerization domain containing 5
  Rac GTPase activating protein 1
  SCY1 like pseudokinase 2
  SP140 nuclear body protein like
  SREK1 interacting protein 1
  staphylococcal nuclease and tudor domain containing 1
  tRNA methyltransferase 6
  UHRF1 binding protein 1
  vir like m6A methyltransferase associated
  VPS50 subunit of EARP/GARPII complex
  V-set and immunoglobulin domain containing 8
  WD repeat domain 91
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  zinc finger protein 512B
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.