IRAG1, inositol 1,4,5-triphosphate receptor associated 1

IRAG1, inositol 1,4,5-triphosphate receptor associated 1

• This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

• Gene Synonyms (IRAG, JAW1L, MRVI1, inositol 1,4,5-triphosphate receptor associated 1, IP3R-associated cGMP kinase substrate, JAW1-related protein MRVI1, inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate, inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, murine retrovirus integration site 1 homolog,)
• NCBI Gene ID: 10335
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y6F6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inositol 1,4,5-triphosphate receptor associated 1 interacts with:

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