AKAP13, A-kinase anchoring protein 13

AKAP13, A-kinase anchoring protein 13

• The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

• Gene Synonyms (A-kinase anchor protein 13, A kinase (PRKA) anchor protein 13, LBC oncogene, breast cancer nuclear receptor-binding auxiliary protein, guanine nucleotide exchange factor Lbc, human thyroid-anchoring protein 31, lymphoid blast crisis oncogene, non-oncogenic Rho GTPase-specific GTP exchange factor, protein kinase A-anchoring protein 13, AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47,)
• NCBI Gene ID: 11214
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q12802
  UNIPROT ID#>>A8MYJ1
  UNIPROT ID#>>B0AZU4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

A-kinase anchoring protein 13 interacts with:

• autophagy related 16 like 1
  centromere protein E
  egl-9 family hypoxia inducible factor 3
  F-box and WD repeat domain containing 11
  ligand of numb-protein X 1
  microtubule associated protein 1 light chain 3 alpha
  protein kinase, cAMP dependent regulatory, type II alpha
  protein kinase, cAMP dependent, catalytic, beta
  ring finger protein 123
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.