MTPN, myotrophin

MTPN, myotrophin

• The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

• Gene Synonyms (GCDP, V-1, myotrophin, granule cell differentiation protein, protein V-1,)
• NCBI Gene ID: 136319
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P58546
  UNIPROT ID#>>Q69YG1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myotrophin interacts with:

• GTPase, IMAP family member 8
  methionine sulfoxide reductase B3
  SAS-6 centriolar assembly protein
  spindle and centriole associated protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.